Evolution of cellular stress response mechanisms
نویسندگان
چکیده
منابع مشابه
Modularity of stress response evolution.
Responses to extracellular stress directly confer survival fitness by means of complex regulatory networks. Despite their complexity, the networks must be evolvable because of changing ecological and environmental pressures. Although the regulatory networks underlying stress responses are characterized extensively, their mechanism of evolution remains poorly understood. Here, we examine the evo...
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MOTIVATION Stress response in cells is often mediated by quick activation of transcription factors (TFs). Given the difficulty in experimentally assaying TF activities, several statistical approaches have been proposed to infer them from microarray time courses. However, these approaches often rely on prior assumptions which rule out the rapid responses observed during stress response. RESULT...
متن کاملAdaptive Evolution of a Stress Response Protein
BACKGROUND Some cancers are mediated by an interplay between tissue damage, pathogens and localised innate immune responses, but the mechanisms that underlie these linkages are only beginning to be unravelled. METHODS AND PRINCIPAL FINDINGS Here we identify a strong signature of adaptive evolution on the DNA sequence of the mammalian stress response gene SEP53, a member of the epidermal diffe...
متن کاملTranslational reprogramming in cellular stress response.
Cell survival in changing environments requires appropriate regulation of gene expression, including translational control. Multiple stress signaling pathways converge on several key translation factors, such as eIF4F and eIF2, and rapidly modulate messenger RNA (mRNA) translation at both the initiation and the elongation stages. Repression of global protein synthesis is often accompanied with ...
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ژورنال
عنوان ژورنال: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology
سال: 2020
ISSN: 2471-5638,2471-5646
DOI: 10.1002/jez.2347